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Skin Deep Dive SS23 - Unveiling the Secrets of Skincare

"SKIN DEEP DIVE" - Unveiling the Secrets of Skincare

Skincare, a seemingly simple and pleasurable pursuit, conceals profound contemplations and meticulous research. Our skin, a fascinating ecosystem, boasts intricate layers and interconnected wonders, all demanding a holistic approach. To unlock the beauty of skincare, let’s embrace both the poetic allure and the rational principles. Welcome to the poetic realm of our SKIN DEEP DIVE, where we unravel the hidden truths of this captivating lifelong journey. Join us as we dive into the fascinating world of skincare revelations, and together, we'll conquer the secrets that lie beneath the surface.


01 Nip the Spring Allergy in the Bud: The Fourfold Armor of the Skin Barrier

Our skin, consisting of the epidermis, dermis, and subcutaneous tissues, is not only robust and resilient but also equipped with a remarkable defense system. The skin barrier serves a dual purpose: shielding our body from external harmful factors and preventing the loss of internal moisture and nutrients.

In this article, we will explore the four essential components of the skin barrier and their crucial roles in maintaining the skin's health and well-being.

1) Skin Microbiota Barrier:

The surface of our skin hosts a diverse array of microorganisms, creating a symbiotic relationship when the skin and microbes are in a balanced state. This beneficial coexistence provides a habitat for microorganisms while offering protective benefits to the skin.

2) Sebum Barrier:

Composed of intercellular lipids, sebum, and sweat, the sebum barrier forms the outermost line of defense in the skin barrier structure. The lipids present in sebum act as a natural lubricant, keeping the skin supple and reducing water evaporation from its surface.

3) Stratum Corneum Barrier:

The stratum corneum barrier consists of keratinocytes and the lipids that interlock them, resembling a sturdy "brick-and-mortar structure." Keratinocytes serve as the "bricks," while lipids act as the "mortar." This resilient and compact structure acts as the primary shield against external substances and prevents excessive water loss.

4) Immunity Barrier:

Comprised of keratin-forming cells, skin dendritic cells, T cells, and immunoreactive factors, the immunity barrier plays a vital role in initiating the skin's immune defense mechanism. When harmful substances breach the fortress walls and enter the skin, the immunity barrier springs into action, safeguarding our skin health.

The synergy among these four barriers forms a comprehensive protective system that defends the skin and maintains the stability of the internal environment. Understanding and nurturing the skin barrier is essential for preserving its health and achieving a vibrant and resilient complexion.


02 Nip the Spring Allergy in the Bud: The Truth of Barrier Damage


In our previous discussion, we highlighted the vital role played by the skin's fourfold barrier system in maintaining stability. However, when any of these barriers are disrupted, the overall function of the skin barrier is compromised.

Such damage to the skin barrier allows external irritants, bacteria, and chemicals to penetrate, akin to a breach in a fortress wall, enabling harmful substances to infiltrate. This intrusion can lead to sensations of tingling, burning, and redness, triggering both neurological and immune responses. Additionally, accelerated moisture loss and nutrient depletion may occur, potentially resulting in the development of dermatitis. Clinically, transepidermal water loss (TEWL) and the water content of the skin serve as common indicators to assess skin barrier function.


Reasons for Barrier Damage:

Numerous factors contribute to skin barrier damage, including incorrect skincare habits, fluctuations in climate and environment, and certain skin diseases. For instance, long-term use of lipid-removing cleansing products (such as cleansing masks and frequent makeup removal) or the excessive layering of potent skincare products (e.g., acid exfoliants, whitening agents, retinol) without considering the skin's condition can deplete the skin's natural lipids and compromise the integrity of the keratin layer. Furthermore, the frequent use of masks can disrupt the balance of the stratum corneum, leading to excessive hydration and structural weakening, thus impairing the barrier function.


Impact on Different Skin Types:

Research indicates that individuals with normal skin exhibit the most optimal barrier function. Conversely, those with dry or oily skin types may experience varying degrees of impairment, particularly in the cheek area. This is evidenced by significantly increased transepidermal water loss, elevated pH levels, and heightened serine protease activity. Notably, there are distinctions between dry and oily skin types. Dry skin primarily manifests a notable decrease in stratum corneum adhesion, while oily skin demonstrates a more pronounced decline in stratum corneum integrity.


Understanding the underlying factors contributing to barrier damage and its impact on different skin types allows us to take proactive steps in maintaining a resilient and healthy skin barrier. Stay tuned for our next posts, where we'll explore the link between sensitivity and barrier damage, and the effective strategies to restore and protect your skin barrier.


03 Nip the Spring Allergy in the Bud: How is Sensitivity Caused by a Damaged Barrier?

Sensitive skin (SS) refers to a state of hyperreactivity of the skin under physiological or pathological conditions. Clinically, it is characterized by subjective symptoms such as burning, tingling, itching, and tightness, accompanied by objective signs like erythema, scaling, and capillary dilation.


When the skin barrier function is compromised, the protective capacity of the skin's nerve endings diminishes, leading to an increase in sensory nerve signals. This heightened responsiveness to external stimuli occurs through activating the transient receptor potential vanilloid subtype 1 receptor (TRPV-1), transmitting sensations of pain, burning, itching, and other stimuli.


Excess expression of TRPV-1 induces secretion of endothelin (ET)-1 from mast cells and endothelial cells, which further promotes the production of Vascular Endothelial Growth Factor (VEGF), resulting in increased vascular reactivity, vasodilatation, and increased blood flow to the skin, causing as redness and swelling of the skin.


Activation of TRPV-1 also leads to the release of inflammatory factors IL-23 and IL-31 from keratinocytes and mast cells near sensory nerve endings. It activates antigen-presenting cells and T cells, thus triggering an immune and inflammatory response in the skin.


A compromised skin barrier weakens the skin's ability to defend against external pathogens, potentially leading to the development or exacerbation of various skin conditions. Research has shown that when the skin barrier is intact, Langerhans cells can identify cutaneous commensal bacteria without triggering an immune response. However, after barrier damage, commensal bacteria that are normally harmless, including bacteria, fungi, and viruses, can penetrate the dermis, be recognized by dendritic cells, and activate the immune system, inducing inflammation. Consequently, when the skin barrier function is disrupted, it can aggravate many immune-related skin conditions such as eczema, atopic dermatitis, and psoriasis.


To address barrier damage or prevent it in advance, several strategies can be employed. When outdoors, minimizing exposure to wind and sunlight helps prevent excessive dryness of the stratum corneum. During cleansing routines, it is advisable to opt for gentle cleansers containing amino acids rather than soap-based ingredients that can be harsh on the skin. Additionally, reducing unnecessary face washes is beneficial.


When selecting skincare products, prioritize repair formulations that are suitable for sensitive skin. We recommend products enriched with hydrating ingredients such as Hyaluronic Acid, Ceramides, and Ectoin, known for their effective stability maintenance. Above all, focusing on enhancing the skin's intrinsic barrier function is crucial to reveal its innate natural beauty.


04 Nip the Spring Allergy in the Bud: A Multi-Dimensional Solution for Skin Barrier Repair

Repairing the skin barrier involves addressing the causes of damage and replenishing its integrity. Causes such as peeling barrier damage, commonly associated with acid treatments and excessive skin cleansing, as well as sun damage that penetrates deeper than the outer layer, should be avoided. Additionally, it is crucial to repair the damaged barrier and preserve the structural integrity of the skin.


The skin barrier consists of four interconnected layers: the Skin Microbiota Barrier, Sebum Barrier, Stratum Corneum Barrier, and Immunity Barrier. These layers work harmoniously, making it challenging for a single-ingredient solution to address complex skin conditions effectively. Therefore, a synergistic approach to repairing all four aspects of the barrier is the recommended skincare strategy by SIMPLY THIS.


The Stratum Corneum Barrier, as the core component, maintains stability by replenishing missing cellular lipids and promoting the renewal of keratinocytes. The Sebum Barrier minimizes water loss by supplementing the skin's lipids, while probiotics foster the growth of beneficial bacteria, maintaining a balanced micro-ecology and enhancing the skin's defense mechanism. The Immunity Barrier protects immune cells, boosting the skin's immunity and providing relief and suppression of ongoing immune responses, ultimately reducing the spread of inflammation.


To address these barrier concerns, Simply This presents the Micro Essence Toner and Probiotic Revitalizing Cream, formulated with the Originomics R² Complex™. This innovative complex replenishes the barrier's missing intercellular lipids, revitalizes keratinocyte differentiation and renewal, and delivers multi-beneficial ingredients that nourish the skin from the surface to the deeper layers. These products deeply hydrate, lock in moisture, and immediately relieve redness while improving the skin's health.


Considering the dynamic nature of the skin, which is constantly influenced by internal and external factors, maintaining a stable skin barrier function requires a balanced approach: minimizing damage, maximizing protection, and prioritizing repair.

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