Sensitive skin is a globally prevalent subhealthy skin condition — epidemiological studies show a prevalence rate exceeding 60% — yet its clinical management remains hampered by unclear pathological mechanisms and the absence of standardized diagnostic and treatment criteria. Current consensus holds that sensitive skin is a clinical syndrome triggered by a combination of intrinsic factors (genetic susceptibility, neurological stress) and extrinsic factors (UV radiation, physical and chemical irritants), presenting mainly as subjective symptoms such as burning and tightness on the face, often accompanied by objective signs like mild redness and swelling.
However, for this widespread skin concern, current common interventions (such as antihistamines) primarily offer temporary symptom relief. There remains a lack of effective solutions that address the root cause — structural defects in the skin barrier — making it urgent to develop targeted intervention strategies grounded in the underlying pathological mechanisms.
In response, Simply This, drawing on a correlation map of sensitive-skin traits, identified the most critical contributing factor as the core target within the matrix, and combined ceramide liposomes with lactobacillus fermentation lysate to create a composite ingredient addressing recurring skin sensitivity — Barrierᴿ.
PPI Network Diagram of Potential Targets for Lactobacillus Fermentation Lysate (L-Lactic Acid) and Ceramide in Improving Skin Sensitivity/Fragility
Through network pharmacology analysis, Simply This identified a total of 14,703 targets associated with skin sensitivity and fragility. By intersecting these with the targets of ceramide liposomes and lactobacillus fermentation lysate, 340 core overlapping targets were identified. In vitro cell experiments confirmed that Barrierᴿ modulates hub proteins such as tSRC, PIK3R1, MAPK1, and AKT1, jointly regulating the PI3K-AKT signaling pathway and the Adherens junction pathway, effectively improving the characteristic responses of sensitive skin. It also reduces the expression of key proteins in the PI3K/AKT pathway and rebuilds the tight junction protein network, effectively repairing skin barrier function.
mRNA Expression Levels of SRC, MAPK1, and AKT1 in Each Group
For sensitivity concerns, Simply This offers an unconventional yet fundamentally effective solution. It effectively reduces histamine-induced cellular inflammatory responses, making cells’ reaction to inflammatory stimuli more stable, and demonstrates a strong anti-inflammatory effect. Through multi-target, multi-pathway synergy, it improves the symptoms of skin sensitivity and fragility, offering comprehensive support and protection for skin health.